Maureen L. Mulvihill,Kevin A. Snook,Rob Van Ess, II,Ryan S. Clement,Jason A. Showers,Andrew J. Meehan,Roger B. Bagwell
申请号：
US15130665
公开号：
US20160303360A1
申请日:
2016.04.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A transdermal delivery system including a first passive portion containing a substance for delivery in a reservoir and a second active portion that includes an ultrasonic source. The ultrasonic source includes piezoelectric element(s) that receive electrical stimulation and move radially. A support member fixed to one side of the piezoelectric element(s) restricts movement at that side, so the opposite side expands and contracts. A fulcrum attached to the support member opposite of the piezoelectric element(s) provides an anchor point about which the piezoelectric element(s) bends and flexes upon electrical stimulation. This provides a low ultrasound frequency with a smaller sized transducer than previously known. The active portion is applied to provide electrical stimulation for a certain length of time and removed, whereas the passive portion may remain for a longer duration. A feedback loop also monitors and adjusts the electrical stimulation to maintain a uniform or constant resonance frequency.
