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MODIFIED SINGLE STRAND POLYNUCLEOTIDE
专利权人:
发明人:
KOIZUMI MAKOTO,HIROTA YASUHIDE,NAKAYAMA MAKIKO,IKEDA MIKA
申请号:
IN1064/MUMNP/2013
公开号:
IN2013MN01064A
申请日:
2013.06.06
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
Provide is a polynucleotide or the like having RNA interference activity and which is stable with respect to RNA splitting enzyme. This single strand polynucleotide is derived from a double strand polynucleotide having a sense strand polynucleotide for a target gene and an antisense strand polynucleotide having a complementary base sequence to said sense strand polynucleotide and has a structure wherein the 5 terminal of this antisense strand and the 3 terminal of the sense strand are respectively bonded by a linker containing a phenyl group that forms a phosphodiester structure.
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