General formula (I) of the present invention [4,5-c] pyridine-4-carbonitrile derivatives, cathepsin S related diseases and pharmaceutical compositions containing said derivatives, such as atherosclerosis, obesity, inflammation and 6-phenyl-imidazo -1H- having immune diseases, chronic pain such as rheumatoid arthritis, psoriasis, and cancer, for example, the use of these derivatives in the manufacture of a medicament for the treatment of neuropathic pain.本発明は一般式(I)を有する6-フェニル-1H-イミダゾ[4,5-c]ピリジン-4-カルボニトリル誘導体、前記誘導体を含有する医薬組成物及びカテプシンS関連疾患、例えばアテローム性動脈硬化症、肥満症、炎症及び免疫疾患、例えば関節リウマチ、乾癬、癌並びに慢性疼痛、例えば神経因性疼痛の治療用医薬の製造におけるこれらの誘導体の使用に関する。
