The present invention provides a liposome composition containing an insoluble drug used for treating a life threatening disease. The preferred method of encapsulating the drug inside the liposome is by remote or active loading. The remote loading of the drug into a liposome containing a membrane pass electrochemical gradient is initiated by co-mixing the liposome suspension with a solution of the drug, whereby the neutral form of the compound enters the liposome freely and charges electrostatically, Prevent reverse transmission to the outside. There is a continuous build-up of the compound into the interior of the liposomes until the electrochemical gradient is eliminated or until all of the drug is encapsulated in the liposome. However, these procedures described in the literature have been limited to drugs that are either soluble in aqueous solution or dissolved as a water soluble complex. The present invention describes compositions and methods for remote loading drugs with low water solubility (<； 2 mg / mL). In a preferred embodiment, the drug in the solubilizer is mixed with the liposome during the aqueous suspension, whereby the concentration of the solubilizer is lowered to its low capacity to completely dissolve the drug. This causes drug precipitation but retains the ability to remotely load. The process is scalable, and in liposomes optimized for lipid compositions and remotely loaded formulations, the resulting drug-loaded liposomes have a high drug-to-lipid ratio and long-term drug retention when the liposomally encapsulated drug is administered to the subject .본 발명은 생명 위협 질환을 치료하기 위해 사용되는 난용성 약물을 함유하는 리포좀 조성물을 제공한다. 리포좀 내부에 약물을 캡슐화하는 바람직한 방법은 원격 또는 능동적 부하에 의한다. 막통과 전기화학적 구배를 함유하는 리포좀으로의 약물의 원격 부하는 리포좀 서스펜션을 약물의 용액과 공-혼합하여 개시되고, 이로써 중성 형태의 상기 화합물은 자유롭게 리포좀에 들어가고 정전기적으로 전하를 띄고 그렇게 함으로써 리포좀 외부로 역전달을 방지한다. 전기화학적 구배가 소면되거나 모든 약물이 리포좀에서 캡슐화될 때까지 리포좀 내부 내로 화합물의 연속적 빌드-업이 있다. 그러나, 문헌에 기재된 이러한 과정은 수용액에서 자유로운 가용성이거나 수용성 복합물로서 용해되는 약물로 제한되었다. 본 발명은 낮은 수용해도 (<
