A method of moisturizing while decolonizing mammalian tissue, the method comprising applying a multi-valent cationic antiseptic composition to the tissue, and applying a moisturizer composition to at least a portion of the same tissue； wherein the mammalian tissue is oral tissue of a subject； wherein the multi-valent cationic antiseptic is other than a metal ion； and wherein the applied compositions essentially exclude any component which causes a precipitate when combined with a multi-valent cationic antiseptic contained in the multi-valent cationic antiseptic composition when tested according to Test Method F, and/or wherein the moisturizer composition is such that a log reduction in the number of viable bacterial cells of at least 2 is provided when 106 cfu of Pseudomonas aeruginosa are combined with a mixture 1.1 g of the moisturizer composition and 1.5 g of the multi-valent cationic antiseptic composition containing 0.12 weight percent of the multi-valent cationic antiseptic according to Test Method B； an oral care kit comprising a composition comprising the multi-valent cationic antiseptic and the moisturizer composition； and a method of moisturizing oral tissue of a patient requiring intubation using the moisturizer composition and an endotracheal tube coated or impregnated with a cationic antiseptic are provided.L'invention concerne un procédé simultané d'hydratation et de décolonisation d'un tissu de mammifère, le procédé comprenant l'application d'une composition antiseptique cationique multivalente sur le tissu et l'application d'une composition hydratante sur au moins une partie de ce même tissu； le tissu de mammifère étant un tissu buccal d'un sujet； et l'antiseptique cationique multivalent n'étant pas un ion métallique. Les compositions appliquées excluent essentiellement tout composant qui provoque un précipité lorsqu'il est combiné avec un antiseptique cationique multivalent contenu dans la composition antiseptique cationique multivalente, lors d'un
