It possesses1 EP receptor competition operation, chemical compound (i) of this invention< Formula >(In formula, A is benzene ring and the like,1 Y is1-6 C alkylene basis,2 Y is single bond and the like,1 R, is the hydrogen atom and1-6 C alkyl group etc,2 R is the aromatic heterocycle of 5 where it is possible to possess the phenyl group and the substituent which are possible to possess the substituent and the aromatic heterocycle etc of 6 membered-rings which are possible to possess the substituent,3 R is the halogen atom and1-6 C alkoxy group etc,4 R is the hydrogen atom and the like, R displays the hydrogen atom and the like), and is something which offers the salt which that pharmacology is allowed. Furthermore, it can utilize chemical compound (i) of this invention, as the curative medicine or the preventive glaze of the conditions of LUTS and especially OABs.EP1受容体拮抗作用を有する、本発明の化合物(I)【化】〔式中、Aはベンゼン環等であり、Y1はC1-6アルキレン基であり、Y2は単結合等であり、R1は、水素原子、C1-6アルキル基等であり、R2は置換基を有してもよいフェニル基、置換基を有してもよい5の芳香族複素環、置換基を有してもよい6員環の芳香族複素環等であり、R3はハロゲン原子、C1-6アルコキシ基等であり、R4は水素原子等であり、R5は水素原子等を表す〕、およびその薬理学的に許容される塩を提供するものである。更に、本発明の化合物(I)は、LUTS、特にOABsの諸症状の治療薬または予防薬として利用できる。
