The invention relates to active compound combinations, in particular a fungicidal and/or insecticidal composition, comprising Isotianil (3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide, CAS No 224049-04-1) and and at least one further insecticide of the fiprole group and one further insecticide of the neonicotinoids. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.本發明係有關一種活性化合物組合,特定言之殺真菌與/或殺昆蟲組合物,其包含抑丹尼(Isotianil)(3,4-二氯-N-(2-氰基苯基)-5-異噻唑甲醯胺,CAS No 224049-04-1)與至少另一種芬普類(fiprole)殺昆蟲劑與另一種新菸鹼類殺昆蟲劑。此外,本發明係有關一種治療性或預防性控制植物病原性真菌與/或微生物與/或植物或作物之害蟲之方法,以根據本發明組合於處理種子上之用途,保護種子之方法與經過處理之種子。