Dental prosthesis, systems, and methods of forming and using a dental prosthesis, are provided. An example of a dental prosthesis includes a first manufactured portion shaped to substantially conform to the three-dimensional surface of a root of a tooth to be replaced and a second manufactured portion shaped to substantially conform to the three-dimensional surface of a crown of the tooth. Furthermore, customized manufactured splints to position and fixate a tooth-shaped prosthesis, are provided. Furthermore, a CAD/CAM based methods of and a systems for manufacturing a customized dental prosthesis are provided. The tooth can be scanned to determine its three-dimensional shape and substantially copied using an imaging system in-vitro like a 3D scanner or in-vivo like a cone beam CT system and CNC machinery. Biocompatible material that is suitable to be integrated into the extraction socket and adopted by existing tissue forming the socket can be manufactured or engineered.
