Systems and methods for setting posterior prosthetic teeth in production of upper and lower dentures feature tooth blocks each having inner and outer bodies having upper and lower rows of recesses therein corresponding maxillary and mandibular prosthetic teeth. The recesses of the inner and outer bodies conform to lingual and buccul surfaces of the prosthetic teeth respectively and are shaped and positioned to establish proper positioning of the prosthetic teeth relative to one another when clamped between the bodies. The two tooth blocks accommodate respective ones of left and right prosthetic poster teeth sets. Connection elements between the tooth blocks allow adjustment and subsequent locking of the relative positioning between the left and right teeth sets before setting on mandibular and maxillary casts in an articulator. The two tooth blocks eliminate the need to individually position posterior teeth on each side of the jaw.
