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Method for preparing diaminophenothiazinium compound
专利权人:
プロヴァンス テクノロジーズ
发明人:
ヘロー ミヘル,サヤー ババク
申请号:
JP2009518928
公开号:
JP5460315B2
申请日:
2007.07.12
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
Preparation of diaminophenothiazinium compounds (I) comprises purification of a diaminophenothiazinium (II) under conditions separating the metallic compounds from (II) or deprotection of the amino group using deprotecting agents devoid of metallic compounds. Preparation of diaminophenothiazinium compounds of formula (I) comprises purification of a diaminophenothiazinium of formula (II) under conditions separating the metallic compounds from (II) or deprotection of the amino group using deprotecting agents devoid of metallic compounds. R 1-R 4 : H, 1-6C alkyl (optionally substituted by halo, 1-6C alkoxy, 1-6C alkylcarbonyl or -CONH 2) or aryl (optionally substituted by 1-4C alkyl, halo, 1-6C alkoxy, 1-6C alkylcarbonyl or -CONH 2), preferably H or methyl; R 5-R 1 0 : R 1, F, Cl, Br or I, preferably H; X ->; : (in)organic anion, preferably Cl or OH; R : phenyl/benzyl (optionally substituted by 1-4C (halo)alkyl, halo or nitro), 1-8C alkyl, 1-8C alkyl amino, 1-8C alkoxy, phenyloxy/benzyloxy (optionally substituted on the aromatic ring by 1-4C (halo)alkyl, halo or nitro); and Z : O or S, preferably O. [Image] ACTIVITY : Antimicrobial; Antibacterial; Immunosuppressive; Anti-HIV; Virucide; Antiinflammatory; Hepatotropic; Neuroprotective; Nootropic; Antimalarial; Cytostatic; Neuroleptic; Antimanic; Antidepressant. MECHANISM OF ACTION : None given.
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