Preparation of diaminophenothiazinium compounds (I) comprises purification of a diaminophenothiazinium (II) under conditions separating the metallic compounds from (II) or deprotection of the amino group using deprotecting agents devoid of metallic compounds. Preparation of diaminophenothiazinium compounds of formula (I) comprises purification of a diaminophenothiazinium of formula (II) under conditions separating the metallic compounds from (II) or deprotection of the amino group using deprotecting agents devoid of metallic compounds. R 1-R 4 : H, 1-6C alkyl (optionally substituted by halo, 1-6C alkoxy, 1-6C alkylcarbonyl or -CONH 2) or aryl (optionally substituted by 1-4C alkyl, halo, 1-6C alkoxy, 1-6C alkylcarbonyl or -CONH 2), preferably H or methyl R 5-R 1 0 : R 1, F, Cl, Br or I, preferably H X -> : (in)organic anion, preferably Cl or OH R : phenyl/benzyl (optionally substituted by 1-4C (halo)alkyl, halo or nitro), 1-8C alkyl, 1-8C alkyl amino, 1-8C alkoxy, phenyloxy/benzyloxy (optionally substituted on the aromatic ring by 1-4C (halo)alkyl, halo or nitro) and Z : O or S, preferably O. [Image] ACTIVITY : Antimicrobial Antibacterial Immunosuppressive Anti-HIV Virucide Antiinflammatory Hepatotropic Neuroprotective Nootropic Antimalarial Cytostatic Neuroleptic Antimanic Antidepressant. MECHANISM OF ACTION : None given.본 발명은 유도체(II)의 정제를 위한 단계를 포함하는 디아미노페노티아지늄 형태의 화합물을 제조하는 방법에 관한 것이다.본 발명에 따른 공정으로 부터 생성된 생성물은 고순도를 갖는다. 본원 발명은 또한 상기 화합물들을 약제의 제조에 이용하는 것이다.
