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Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
专利权人:
发明人:
Bertrand Leblond,Thierry Taverne,Cedric Chauvignac,Eric Beausoleil,Anne-Sophie Casagrande,Laurent Desire,Matthew P. Pando,John E. Donello,Rong Yang
申请号:
US14097808
公开号:
US09200016B2
申请日:
2013.12.05
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to compounds of the formulaor a pharmaceutically acceptable salt thereof, wherein R′, R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.
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