니키, 요코,야로쉬, 다니엘 비.,마쯔이, 메리 에스.,요시다, 마사키,이치하시, 마사미츠,안도, 히데야
申请号：
KR1020147017894
公开号：
KR1015849260000B1
申请日:
2011.01.05
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
Compositions and methods for skin lightening and / or color removal are provided, wherein the composition comprises a compound of formula I； Or a compound of formula II； Or stereoisomers and enantiomers which do not contain or are mixed with other enantiomers or stereoisomers, salts, solvates, and biochemical precursors that are acceptable for pharmaceutical, cosmetic, and dermatological applications of these compounds ； The compound is present in a composition comprising a safe and effective amount of a skin lightening or depigmenting compound together with a carrier which is acceptable for its pharmaceutical, cosmetic or dermatological purposes. (I) In the above formula R 1 and R 2 are the same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl (any of which may be halogen-substituted) ； R <； 6 >； is selected from the group consisting of hydrogen, methyl, and ethyl； R 3 , R 4 and R 5 are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, propoxymethoxy and the like, Lt； / RTI >； may be halogen-substituted； <； In the above formula R 2 is hydrogen, lower alkyl or hydroxy lower alkyl； R 3 is lower alkyl, -CH 2 CN, hydroxy lower alkyl, -NO 2 , -CH 2 N = C or (Wherein R <； 6 & And R <； 7 >； are independently selected from the group consisting of hydrogen and lower alkyl) or R <； 2 >； is hydrogen； R 4 is ZTW, wherein Z represents -O-, -NH- or a single bond； T represents a linear or branched lower-alkylene group； When Z is a single bond, T also represents an ethenylene or propenylene group, wherein the unsaturated carbon is in a single bond； When Z is -O-, T also represents an allylene group, wherein the saturated carbon is in oxygen； W is selected from hydrogen [when T is allylene and Z is -O-], and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted
