GUILLEMONT, Jerôme Emile Georges,LANSOIS, David Francis Alain,MOTTE, Magali Madeleine Simone,BALEMANS, Wendy Mia Albert,WEIDNER, Steffen Friedrich Walter,MC GOWAN, David Craig,KOUL, Anil
申请号：
ES13747399
公开号：
ES2639118T3
申请日:
2013.08.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** where the bond (adjacent to X) represents a single bond or a double bond； when it represents a double bond, then X represents C (R4)； when it represents a single bond, then X represents N (R4) or C (R3) (R4)； R1 is hydrogen, C1-4 alkyl or halo； R2 is hydrogen, C1-4 alkyl or halo； Rx represents: ** Formula ** where Xx represents C (H), C (Ry1) or N； Ry1 represents one to three optional substituents each independently selected from hydrogen, halo, -CN, -O- (C1-6 alkyl) or C1-6 alkyl (where these last two alkyl moieties are optionally substituted with one or more fluorine atoms)； each Ry2 and Ry3 independently represents hydrogen or -Q1-R5； each Q1 independently represents a direct link or -C (O) -； R5 represents hydrogen, C1-6 alkyl, heterocycloalkyl (where these last two groups are each optionally substituted with one or more substituents independently selected from>； = O and Q2), aryl or heteroaryl (where these last two groups are optionally substituted with one or more substituents selected from Q3)； Q2 represents halo, -CN, -O (C1-6 alkyl) (optionally substituted with one or more fluorine atoms), aryl or heteroaryl (where these last two groups are optionally substituted with one or more substituents selected from halo, -CN , C1-3 alkyl or -O (C1-3 alkyl), the last two alkyl moieties being in turn optionally substituted with fluoro)； Q3 represents halo, -CN, -O- (C1-6 alkyl) or C1-6 alkyl (where these last two alkyl moieties are optionally substituted with one or more fluoro substituents)； ** Formula ** where Xx represents C (H ) or N； Z1 represents -X1-O-X1a-, -X2-N (Rz3) -X2a- or -X3-S-X3a-； X1, X2 and X3 independently represent a direct link, -C (O) - or -C (Rz4) (Rz5) -； X1a, X2a and X3a independently represent a direct bond or -V1-C (Rz1) (Rz2) -； V1 represents a direct link or -C (O) -； Rz1, Rz2, Rz3, Rz4 and Rz5 independently represent hydrogen, C1-6 alkyl (optionally substituted with one or more substituents selecte
