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縮合吡唑衍生物
专利权人:
LTD.;SUMITOMO DAINIPPON PHARMA CO.
发明人:
YOSHINAGA, HIDEFUMI,吉永英史,URUNO, YOSHIHARU,宇留野义治,宇留野義治,SAWAMURA, KIYOTO,泽村洁人,澤村潔人,GOTO, NANA,後藤奈奈,IKUMA, YOHEI,井熊洋平
申请号:
TW103136543
公开号:
TW201605858A
申请日:
2014.10.22
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The present invention provides cyclic aminomethylpyrimidine derivatives and pharmaceutically acceptable salts thereof which show high selectivity for dopamine D4 receptors and are useful for treating diseases such as attention deficit hyperactivity disorder. In detail, the present invention provides a compound represented by Formula (1): wherein n and m are independently 1 or 2; W1, W3 and W4 are independently a single bond or an optionally-substituted C1-4 alkylene group; W2 is an optionally-substituted C1-4 alkylene group; R1 and R2 are independently a hydrogen atom or the like; R3 is a hydrogen atom, a halogen atom or the like; X1 and X2 are independently a single bond, an oxygen atom or the like; Ring Q1 is an optionally-substituted 5- to 10-membered heteroaryl group or the like; and Ring Q2 is an optionally-substituted 6-membered heteroaryl group or the like or a pharmaceutically acceptable salt thereof.本發明提供一種對多巴胺D4受體顯現選擇性較高之作用,而可用作注意力不足過動症等之治療劑之環狀胺基甲基嘧啶衍生物及其藥學上所容許之鹽。具體而言,本發明係關於一種由式(1)表示之化合物或其藥學上所容許之鹽。[式中,n及m分別獨立地表示1或2;W1、W3及W4分別獨立地表示單鍵、或可經取代之C1-4伸烷基;W2表示可經取代之C1-4伸烷基;R1及R2分別獨立地表示氫原子等;R3表示氫原子、鹵素原子等;X1及X2分別獨立地表示單鍵、氧原子等;環Q1表示可經取代之5員~10員之雜芳基等;環Q2表示可經取代之6員之雜芳基等]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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