Cytotoxic proteins comprising cell-targeted binding regions and Shiga toxin A subunit regions to selectively kill specific cell types

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专利权人:

Inc.;Molecular Templates

发明人:

POMA, Eric,WILLERT, Erin,KIM, Jason,HIGGINS, Jack

申请号：

DK14726015

公开号：

DK2970487T3

申请日:

2014.03.11

申请国别(地区):

DK

年份:

2020

代理人:

摘要：

The present invention provides cytotoxic proteins comprising immunoglobulin-type binding regions for mediating cell-type specific targeting and Shiga toxin effector regions derived from A Subunits of members of the Shiga toxin family for effectuating cytotoxicity. The cytotoxic proteins have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/