PROBLEM TO BE SOLVED: To provide a wound healing agent which can suppress bacterial growth, promote granulation tissue formation or epithelization, and also suppress contracture.SOLUTION: A wound healing agent containing water and protein (A) having GAGAGS sequence (1) and a following amino acid sequence (X) and/or a following amino acid sequence (X), and β-sheet structure rate of (A) by circular dichroism spectrum is 25-60%. Amino acid sequence (X): at least one amino acid sequence selected from a group consisting of VPGVG sequence (2), GVGVP sequence (3), and GAHGPAGPK sequence (4). Amino acid sequence (X): an amino acid sequence in which 1 or 2 amino acids in the amino acid sequence (X) are replaced with ricin or arginine, respectively.COPYRIGHT: (C)2014,JPO&INPIT【課題】菌増殖を抑制し、かつ肉芽組織形成や上皮化を促進し、さらに拘縮抑制できる創傷治癒剤を提供することを目的とする。【解決手段】GAGAGS配列(1)並びに下記アミノ酸配列(X)及び/又は下記アミノ酸配列(X’)を有するタンパク質(A)と水とを含む創傷治癒剤であって、(A)の円二色性スペクトル法によるβシート構造率が25~60%である創傷治癒剤。アミノ酸配列(X):VPGVG配列(2)、GVGVP配列(3)及びGAHGPAGPK配列(4)からなる群より選ばれる少なくとも1種のアミノ酸配列。アミノ酸配列(X’):アミノ酸配列(X)中の1~2個のアミノ酸がそれぞれリシン又はアルギニンで置換されたアミノ酸配列。【選択図】図2
