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КОМПОЗИЦИИ И СПОСОБЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ ГИПЕРТИРЕОЗА У ЖИВОТНЫХ-КОМПАНЬОНОВ
专利权人:
ХИЛЛС ПЕТ НЬЮТРИШН; ИНК. (US)
发明人:
АЛЬ-МУРРАНИ Самер (US),БРОКМАН Джеффри (US)
申请号:
RU2014129530
公开号:
RU2014129530A
申请日:
2012.12.06
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An isolated DNA molecule comprising (a) a nucleotide sequence SEQ ID NO: 1 or (b) a nucleotide sequence completely complementary to the nucleotide sequence of SEQ ID NO: 1.2. An isolated DNA molecule comprising at least 70 contiguous nucleotides of SEQ ID NO: 1 or at least 70 contiguous nucleotides fully complementary to the nucleotide sequence of SEQ ID NO: 1.3. The isolated DNA molecule of claim. 2, wherein the 70 contiguous nucleotides found in the coding sequence of the protein of sodium iodine symporter cats (NIS protein) .4. The isolated molecule of RNAi or antisense nucleic acid molecule selectively binds to a nucleic acid molecule of claim. 1.5. The isolated molecule of RNAi or antisense nucleic acid molecule of claim. 4, wherein the RNAi molecule selectively binds to the protein coding sequence of sodium iodine symporter cats (NIS protein) .6. An isolated protein is from 8 to 400 amino acids in length comprising the amino acid sequence of SEQ ID NO: 2.7. An isolated antibody that selectively binds to a peptide of SEQ ID NO: 2.8. An antibody according to claim. 7 wherein the antibody is at least one of the monoclonal, polyclonal, chimeric, single chain anti-idiotypic or antitela.9. The cell line, hybridoma, phage or transgenic organism producing the antibody according to claim. 7.10. An antibody according to claim. 7 wherein the antibody is combined with a composition selected from the group consisting of the analyte and the therapeutic sredstv.11. A composition comprising an antibody according to claim. 7 and a pharmaceutically acceptable nositel.12. An isolated antibody fragment according to claim 7, wherein the antibody fragment comprises a moiety selected from the group consisting of: a) Fab-fragment. b) F (ab ) - fragment and c) Fv-fragmenta.13. A method for modulating the activity1. Выделенная молекула ДНК, содержащая (a) нуклеотидную последовательность SEQ ID NO:1 или (b) нуклеотидную последовательность, полностью комплементарную нуклеотидной после
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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