CLOGSTON CHRISTI L.,CHRISTIAN TWINKLE R.,FREEMAN ELISABETH,OSSLUND TIMOTHY D.
申请号：
ARP120101010
公开号：
AR085575A1
申请日:
2012.03.26
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Claim 1: a glass which comprises a antiescleroso IgG Antibody variable regions of Light And Heavy Chains of SEQ ID no. 3 and 5, preferably with the amino acid sequences of SEQ ID nos. 13 and 15.Claim 2: a sterile formula that includes a Crystal of a antiescleroso IgG Antibody, characterized in that at least 70% of the Antibody has Crystalline form.Claim 8: glass or formula of any preceding claim, characterized in that the Crystal contains a Salt selected from the Group containing SODIUM DIHYDROGEN PHOSPHATE, Dipotassium hydrogen phosphate, Sodium Chloride, AMMONIUM SULFATE, tetrahid tartrate While tacsimato, sodium and potassium, SODIUM CITRATE DIHYDRATE, SODIUM ACETATE TRIHYDRATE,Diammonium tartrate, malonate, SODIUM ACETATE, calcium acetate, Lithium cacodylate, Ches, sulfate, Magnesium chloride, Zinc acetate, CESIUM CHLORIDE, ammonium phosphate, Sodium Phosphate, POTASSIUM PHOSPHATE, Sodium fluoride, potassium iodide, Sodium iodide, ammonium iodide, tiocianat Or Sodium, POTASSIUM THIOCYANATE, SODIUM FORMATE, formate Potassium and Ammonium formate.Claim 15: The formulae of Claims 11 or 12, which, when administered to subjects in Mammals, an increase in bone mineral density that is at least approximately 70% of the level of bone mineral density mediated by a Liquid formula such that no antibody It has been Crystallized.Wherein the liquid formula and the formula of the Antibody has not been CRYSTALLIZED is administered to the subject in the same Dose in the same way. Claim 18: a container comprising at least 50 mg Crystal Antibody of claim 1 for its suspension in a volume of 0.5 ml - 2.Claim 24: a method for producing a Crystal of a antiescleroso IgG Antibody, which comprises variable regions of Light And Heavy Chains of SEQ ID no. 3 and 5, preferably with the amino acid sequences of SEQ ID nos. 13 and 15, the method comprising Combination A solution with an Antibody reactive CrystallizationIt is a Salt selected from the Group containing SODIUM DIHYDROGEN PHOSPHATE,
