A biopsy device (100, 200) comprising: a cannula (102； 202) comprising an elongate cannula body (106) extending between a cannula distal end (108) and a cannula proximal end (110) to define a lumen, wherein the cannula (102； 202) comprises a cutting portion (112) at the cannula distal end (108)； a stylet (104) comprising an elongate body (114) having a stylet distal end (116) and a stylet proximal end (118), the stylet (104) being slidably disposed within the lumen, wherein the stylet (104) comprises a tissue sampling portion (120). The tissue sampling portion (120) is formed by a notch in the body of the stylet (104) at or near the stylet distal end. The biopsy device (100； 200) further comprises an actuator assembly (126； 226), the actuator assembly arranged to move the cannula (102； 202) relative to the stylet (104； 204) between a retracted position in which at least part of the tissue sampling portion (120) is exposed and an extended position in which the cannula (102； 202) at least partly surrounds the tissue sampling portion (120). The actuator assembly (126； 226) comprises a cannula actuator (128； 228) moveable between a primed configuration and an actuated configuration to move the cannula (102； 202) between the retracted position and the extended position. The biopsy device (100； 200) further comprises a selective coupling mechanism (130； 230) arranged to provide a selective coupling between the actuator assembly and one or both of the stylet and the cannula.
