the present invention relates to a method for the production of pharmaceutical granulation moisture \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u0435\u043c\u043e\u043c\u0443 drug formcontaining at least one sensitive to moisture active substance selected from the group consisting of \u0430\u043b\u0438\u0441\u043a\u0438\u0440\u0435\u043d\u0430 and his \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438 acceptable salts, ef \u0438\u0440\u043e\u0432 and \u0441\u043e\u043a\u0440\u0438\u0441\u0442\u0430\u043b\u043b\u043e\u0432,includes: (a) mixing the active substances (substances) with one or more dry \u044d\u043a\u0441\u0446\u0438\u043f\u0438\u0435\u043d\u0442\u043e\u043c in solid form, with the \u044d\u043a\u0441\u0446\u0438\u043f\u0438\u0435\u043d\u0442 is selected, in particular, of group of dilutents,surface active agents, binders, \u0441\u043c\u0430\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0445 substances \u0440\u0430\u0437\u0440\u044b\u0445\u043b\u0438\u0442\u0435\u043b\u0435\u0439, auxiliary substances for granulation, the buffer \/ \u043f\u043e\u0434\u0449\u0435\u043b\u0430\u0447\u0438\u0432\u0430\u044e\u0449\u0438\u0445 agentsfillers and antioxidants (b) bringing the mixture into contact with a fluid containing water for granulation, and possibly one or more \u044d\u043a\u0441\u0446\u0438\u043f\u0438\u0435\u043d\u0442, obtaining \u0433\u0440\u0430\u043d\u0443\u043b\u044f thewith the \u044d\u043a\u0441\u0446\u0438\u043f\u0438\u0435\u043d\u0442 is selected, in particular, from the group consisting of binders, the buffer \/ \u043f\u043e\u0434\u0449\u0435\u043b\u0430\u0447\u0438\u0432\u0430\u044e\u0449\u0438\u0445 agents, surface active agents and an. \u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043e\u0432,to obtain the production the mass ratio of total water quantity, and the total number of all solid components, including the solid substance (substance) and i \u0432\u043d\u0443\u0442\u0440\u0438\u04
