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Fusion Protein of Protein fragments to create compositions of natural human immunoglobulin FC multimerizadas orderly
专利权人:
GLIKNIK INC.
发明人:
OLSEN HENRIK,BLOCK DAVID S.
申请号:
ARP110102729
公开号:
AR082404A1
申请日:
2011.07.28
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
A series of recombinant immunoglobulins In this way, the immunoglobulin (FC) multivalent appears on the receptor of immune cells. Fusion proteins exist as highly clean homogeneous and polycrystalline parts, called stradomers (biomolecules). Compared with the homogeneous part, the pure multiamerican stradomers have stronger affinity, enthusiasm and lower dissociation with fcgrs (FCG receiver),They are useful in the treatment and prevention of diseases. It has been proved that the direct combination of FC area and multi beautification field of the global biodiversity and Ecological Management Institute 1 has led to greater multi beautification and biological activities. A treatment for inflammation, autoimmune disease, or infectious disease. A way to prevent the binding of nonspecific in vitro or preactive antibodies One way to reduce the endocrine level: component 1: a unit of stratomer, which is characterized by (a) an instruction sequence, (b) a partial domain of IgG1, and (c) a multiple domain,Among them, the instruction sequence is directly connected to the Fc domain of IgG1, while the Fc domain of IgG1 is directly connected to the multi-functional domain.Una serie de formas de inmunoglobulinas Fc multimerizadas totalmente recombinantes. De este modo se presentan inmunoglobulinas Fc polivalentes a los receptores de células inmunes. Las proteínas de fusión existen como fracciones homodiméricas y multiméricas altamente ordenadas, denominadas Stradomers (moléculas biomiméticas). En comparación con la fracción homodimérica, las Stradomers multiméricas purificadas tienen una mayor afinidad y avidez por los FcgRs (Receptores Fcg) con una menor disociación, y son de utilidad en el tratamiento y la prevención de enfermedades. Se demuestra que la unión directa de regiones Fc de la IgG1 a dominios de multimerización conduce a una mayor multimerización y actividad biológica. Método parta tratar una enfermedad inflamatoria, una enfermedad autoinmune o una enfermedad infeccio
来源网站:
中国工程科技知识中心
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