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Whitening agent and skin external preparation
专利权人:
Kimihiro Ogino;Naoto Hanyu;Takako Shibata;Tomoko Saito;Kiyoshi Sato
发明人:
Naoto Hanyu,Tomoko Saito,Takako Shibata,Kiyoshi Sato,Kimihiro Ogino
申请号:
US12866250
公开号:
US08563552B2
申请日:
2009.02.06
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof:wherein X1, X2, and X3 are each CR2 or N; R1, R2, and R3 are each H, C1-6 alkyl, C1-6 alkoxy, SH, OH, or NRbRc, wherein Rb and Rc are each H, C1-6 alkyl, or hydroxy-C1-6 alkyl, or NRbRc forms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R1, R3, R4, and R6 is a group other than C1-3 alkyl in the case where X1═X2═Y1═N and X3═CR2.
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