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Criptoficina conjugated compounds and Products, their Preparation and therapeutic use
专利权人:
SANOFI
发明人:
申请号:
ARP160103379
公开号:
AR106604A1
申请日:
2016.11.04
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
1. Claim 1: a formula cipher compound (1),e. R1 represents a c8321 rent group;R2 and R3 represent independent,a. Hydrogen atom or c832131 asphalt group;or alternatively R² and R³ together with the carbon atom to which a C ciclo cycloalkyl or C₃₋₆ heterocycloalkyl group are attached;R83088 and r83099 respectively represent:a hydrogen atom or a C₁₋₆ alkyl group or a C₁₋₆-NH alkyl group (R¹²) or a C₁₋₆-OH alkyl group or a C₁₋₆-SH alkyl group or a C₁₋₆-CO₂H alkyl group ; or alternatively R⁴ and R⁵ together with the carbon atom to which a C ciclo cycloalkyl or C₃₋₆ heterocycloalkyl group are attached;R⁶ represents a hydrogen atom or a C₁₋₆ alkyl group;R831111 and r831222 respectively represent:a hydrogen atom or a C₁₋₆ alkyl group or a C₁₋₆-CO₂H alkyl group or a C₁₋₆-N- (C₁₋₆ alkyl) ₂ alkyl group;or alternatively R⁷ and R⁸ together with the carbon atom to which a C ciclo cycloalkyl or C₃₋₆ heterocycloalkyl group are attached;R8313 represents one or more alternatives to independently selected phenyl nuclei,between: a hydrogen atom, -OH, C₁₋₄ alkoxy,One halogen atom, nh832222,-NH-C₁₋₆ alkyl or -N (C₁₋₆ alkyl) ₂ or -NH-C₁₋₆ cycloalkyl or C₃₋₆ heterocycloalkyl;R¹⁰ represents at least one substituent of the phenyl core selected from a hydrogen atom and C₁₋₄ alkyl;W represents C₁₋₆-NH (R¹¹) alkyl,C₁₋₆-OH alkyl, C₁₋₆-SH alkyl, CO₂H or C (= O) NH₂;C₁₋₆-CO₂H alkyl or C₁₋₆-C alkyl (= O) NH₂;or C₁₋₆-N₃ alkyl;R1 and R1 represent, independent,a. Hydrogen atom or c8332131 hydrocarbon 832626;Reivindicación 1: Un compuesto de criptoficina de fórmula (1), en donde : R¹ representa un grupo alquilo C₁₋₆; R² y R³ representan, independientemente entre sí, un átomo de hidrógeno o un grupo alquilo C₁₋₆; o alternativamente R² y R³ forman junto con el átomo de carbono al que están anclados un grupo cicloalquilo C₃₋₆ o heterocicloalquilo C₃₋₆; R⁴ y R⁵ representan, independientemente entre sí, un átomo de hidrógeno o un grupo alquilo C₁₋₆ o un grupo alquil C₁₋₆-NH(R¹²) o un grupo alquil C₁₋₆-OH o
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