FEDERAL STATE BUDGETARY INSTITUTION "RESEARCH CENTER OF NEUROLOGY" RUSSIAN ACADEMY OF MEDICAL SCIENCES (FSBI "RCN" RAMS)
发明人:
SUSLINA, Zinaida Alexandrovna,СУСЛИНА, Зинаида Александровна,ILLARIOSHKIN, Sergey Nikolaevich,ИЛЛАРИОШКИН, Сергей Николаевич,STVOLINSKY, Sergey Lvovich,СТВОЛИНСКИЙ, Сергей Львович,BOLDYREV, Alexandr A
申请号：
RURU2013/000191
公开号：
WO2013/141759A2
申请日:
2013.03.13
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The invention relates to medicine, specifically to neurology and cardiology, namely to the production of a drug in the form of a biologically active nanopreparation having antihypoxic and antioxidant activity. The use of liposomal containers comprising L-carnosine for the preparation of a nanopreparation having antihypoxic and antioxidant activity increases the stability of the L-carnosine and the life thereof in an organism whilst increasing the efficiency of the action of L-carnosine in small doses, as well as extending the range of such drugs. The mentioned use of L-carnosine for the preparation of a nanopreparation having antihypoxic and antioxidant activity comprises a combination of L-carnosine with a combination of substances selected from the group consisting of phospholipids and nonpolar lipids with the following ratio of components, in % by mass: L-carnosine - 1.1 - 1.2 nonpolar lipids such as triglycerides, cholesterol, free fatty acids, DL-α-tocopherol - 1.2 - 2.5 phospholipids such as phosphatidylcholine, phosphatidyl ethanolamine, lysophosphatidylcholine, lysophosphatidyl ethanolamine, sphingomyelin - 95.3 - 96.3. In this application as well, the drug prepared is used to improve tolerance to brain ischemia, to improve recovery after acute hypoxia, and to increase the antioxidant status of brain tissues. Furthermore, the drug is produced in the form of liposomes containing L-carnosine.Linvention se rapporte au domaine de la médecine, notamment de la neurologie et de la cardiologie, et concerne la production dun agent médicamenteux sous forme dune nano-préparation bioactive ayant une action anti-hypoxique et anti-oxydante. Lutilisation de contenants liposomaux contenant de la L-carnosine pour la fabrication dune nano-préparation ayant une action anti-hypoxique et anti-oxydante, permet daccroître la stabilité de la L-carnosine et sa durée de vie dans lorganisme afin daugmenter lefficacité de son action à faibles doses, ainsi que délargir léventail de ces
