DISTRIBUTION D'AGENTS THERAPEUTIQUES EMPLOYANT DES SEGMENTS POLYPEPTIDESLIANT UN COLLAGENE BACTERIEN农业专利-农业专业知识服务系统

专利权人:: THE KITASATO INSTITUTE;THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;MONTEFIORE MEDICAL CENTER;NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人:: SAKON, JOSHUA,PHILOMINATHAN, SAGAYA THERESA LEENA,KATIKANENI, RANJITHA,MATSUSHITA, OSAMU,PONNAPAKKAM, TULASI,KOIDE, TAKAKI,GENSURE, ROBERT C.,NISHI, NOZOMU

摘要：: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.