Delivery of therapeutic agents by means of a collagen binding protein农业专利-农业学术服务平台

专利权人:: The Board of Trustees of the University of Arkansas;The Kitasato Institute;Montefiore Medical Center;National University Corporation Kagawa University

发明人:: Sakon, Joshua,Philominathan, Sagaya, Theresa, Leena,Matsushita, Osamu,Ponnapakkam, Tulasi,Koide, Takaki,Nishi, Nozomu,Katikaneni, Ranjitha,Gensure, Robert, C.

摘要：: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.