HOERSTRUP, Simon P.,EMMERT, Maximilian Y.,BAAIJENS, Frank,DRIESSEN-MOL, Anita
申请号：
AU2018326326
公开号：
AU2018326326A1
申请日:
2018.08.28
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention concerns a tissue-engineered medical device, as well as a method for the production said medical device, comprising the following steps: providing a polymer scaffold comprising a mesh comprising polyglycolic acid, and a coating comprising poly-4-hydroxybutyrate； application of a cell suspension containing preferably human cells to the polymer scaffold； placement of the seeded polymer scaffold in a bioreactor and mechanical stimulation by exposure to a pulsatile flux of incremental intensity, thereby forming an extracellular matrix； mounting of the graft on a conduit stabilizer and incubation in cell culture medium； decellularisation of the graft in a washing solution； nuclease treatment of the graft； and rinsing of graft. The invention further comprises and various steps of quality control of the tissue-engineered medical device.
