Méthode pour préparer l'hemihydrate de l'hydrochlorure de (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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专利权人:

ARENA PHARMACEUTICALS; INC.

发明人:

申请号：

EP10010048.6

公开号：

EP2327698B1

申请日:

2005.12.20

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention is directed to methods of preparing ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate comprising at least partially dissolving ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride in a crystallizing solvent containing water, and inducing precipitation of the hemihydrate from the crystallizing solvent.

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