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Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide
专利权人:
Robert L. Ferris
发明人:
Robert L. Ferris,Pedro Andrade,Andres Lopez-Albaitero
申请号:
US12959073
公开号:
US08367069B2
申请日:
2010.12.02
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing a T-cell response in a patient with epithelial cancer, and a method inhibiting epithelial cancer, wherein the methods comprise administering the composition of the invention. The invention further provides a method of stimulating a cell with the inventive polypeptide and a cell so stimulated.
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