Processing of water-insoluble nanoparticles with hydrophilic conjugates of alpha-hydroxyphosphonic acid, modified with such a nanoparticle and their use as contrast agents
1. A composition comprising: a water-insoluble nanoparticle to which at least one alpha hydroxyphosphonate moiety is attached, having the formula: wherein S is a spacer, L is a bond between S and R, R is a polymer hydrophilic moiety, m and p are 1-5, and n and o are 0-5.2. The composition of claim 1, wherein R is a polymer hydrophilic moiety based on ethylene oxide units. The composition according to claim 1 or 2, where the polymer hydrophilic groups are based on ethylene oxide, and where the poly (ethylene oxide) has a molecular weight equal to or less than 5000 Da. The composition of claim 1, wherein the nanoparticle is a superparamagnetic iron oxide based nanoparticle. The composition of claim 1, further comprising a pharmaceutically acceptable carrier or excipient. The composition according to claim 5 for use as an MRI contrast agent (magnetic resonance imaging) suitable for injection to a human subject. A method of using water-insoluble nanoparticles to which alpha-hydroxyphosphonate groups are attached in diagnostic imaging, comprising: administering said nanoparticles to a subject； ib) subjecting said subject to diagnostic imaging in which said nanoparticles act as a contrast agent. The method of claim 7, wherein the alpha hydroxyphosphonate moieties have the formula: wherein S is a spacer, L is a bond between S and R, R is a polymer hydrophilic moiety, m and p are 1-5, and n and o are 0 -5.9. The method of claim 8, wherein R is an ethylene-based polymer hydrophilic moiety�1. Композиция, содержащая:нерастворимую в воде наночастицу, к которой присоединена по меньшей мере одна альфа-гидроксифосфонатная группировка, имеющая формулу:где S представляет собой спейсер, L представляет собой связь между S и R, R представляет собой полимерную гидрофильную группировку, m и p равны 1-5, и n и o равны 0-5.2. Композиция по п.1, где R представляет собой полимерную гидрофильную группировку на основе этиленоксидных единиц.3. Композиция по п.1 или 2, где полимерные гидрофильны
