Antibodies capable of specifically binding to two epitopes on tissue factor coagulation inhibitor

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专利权人:

ノルディスク;アー／エス;ノヴォ

发明人:

ビーリト・オールセン・クローウ,ミケール・コフォード－ハンセン,イーダ・ヒルデン,ヘレ・ハイブロク・ペーテルゼン,ラース・クリスチャン・ペーテルゼン,イェンス・ブラインホルト

申请号：

JP2015562176

公开号：

JP6586016B2

申请日:

2014.03.14

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.

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中国工程科技知识中心

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http://www.ckcest.cn/home/