Berit O. Krogh,Mikael Kofod-Hansen,Ida Hilden,Helle H. Petersen,Lars C. Petersen,Jens Breinholt
申请号：
US14775108
公开号：
US09896513B2
申请日:
2014.03.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.
