THE REGENTS OF THE UNIVERSITY OF COLORADO; a body corporate
发明人:
Thomas ANCHORDOQUY,Jamie L. BETKER
申请号：
US15766088
公开号：
US20180291086A1
申请日:
2016.10.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Lipoplex formulations and uses thereof. In particular, the lipoplexes include at least one naturally-occurring cationic amphiphile, at least one C18-30 saturated fatty acid, cholesterol, at least one nucleic acid, and have a low charge ratio. The lipoplexes are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic therapeutic or an antisense therapeutic, such as an RNAi agent) and allow prolonged expression of these agents, which may be distributed via endogenous cellular pathways to surrounding cells or tissue.
