ВУ Чи Б. (US),БЕМИС Джин Э. (US),ДЖИРОУСЕК Майкл Р. (US),МИЛН Джилл К. (US),СМИТ Джесси Дж. (US)
申请号：
RU2012134069/13
公开号：
RU2012134069A
申请日:
2011.01.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A molecular conjugate comprising fumarate and a fatty acid selected from lipoic acid, omega-3 fatty acids or fatty acids metabolized in vivo to omega-3 fatty acids. The compound of Formula I: or a pharmaceutically acceptable salt, hydrate, solvate, medicament, enantiomer or stereoisomer thereof； wherein each W and W is independently zero, O, S, NH, or NR, or W and W can be taken together to form an optionally substituted imidazolidine or piperazine groups； each a, b, c, and d, is, independently, —H, —D, —CH, —OCH, —OCHCH, —C (O) OR, —OZ, or benzyl, or two of a, b , c and d can be taken together with one carbon to which they are bonded to form a cycloalkyl or heterocycle； each n, o, p and q equals, independently, 0, 1 yl and 2； each L is, independently, zero, -O-, -C (O) -, -S-, -S (O) -, -S (O) -, -SS-, - (C-C1-6alkyl) -, - (C-Cycloalkyl) -, heterocycle, heteroaryl ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,, or； where the representation of L is not limited by the direction from left to right, as shown, rather, either the left side or the right side of L can be connected to the W side of the compound of Formula I； each R is, independently, -H, -D, - C-C1-6alkyl, -halogen, cyano, oxo, thiooxo, -OH, -C (O) C-C1-6alkyl, -O-aryl, -O-benzyl, -OC (O) C-C1-6alkyl, -C-Salken, - C-Salkin, -C (O) C-Calkyl, -NH, -NH (C-Calkyl), -N (C-Calkyl), -NH (C (O) C-Calkyl), -N (C (O ) C-C1-6alkyl), -SH, -S (C-Sal sludge), -S (O) C-C1-6 alkyl, -S (O) C-C1-6 alkyl； each g equals, independently, 2, 3 or 4； each h equals, independently, 1, 2, 3 or 4； each m equals independently 0, 1, 2, or 3； if m is greater than 1, then L can be the same or different； each m1 equals, independently, 0, 1,2, or 3； k equals 0, 1, 2, or 3； z equals 1, 2, or 3； each R represents, independently, H or optionally substituted1. Молекулярный конъюгат, включающий фумарат и жирную кислоту, которая выбирается из липоевой кислоты, омега-3 жирных кислот или жирных кислот, метаболизированных in vivo до омега-3 жирных кисл
