VIVEKANANDAN SUNDARAMOORTHY,P ANANDSENTHILVEL,SAMPATH KUMAR D,JEFFREY STUART BERGMAN
申请号：
IN2437/CHE/2010
公开号：
IN2010CH02437A
申请日:
2010.10.24
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
A novel process of preparing a dexibuprofen pharmaceutical formulation in the form of granules, which can be directly compressed into tablets. The process consists of two steps: (i) preparation of base granule, and (ii) blending of base granules with compression aid to get ready to compress granules, wherein the process of preparing base granules involves use of fluid bed granulator with top spray method. The granules prepared by using fluid bed granulation process showed improved compressibility and flowability compared to granules prepared by conventional granulation process using rapid mixer granulator. Also the granules prepared using fluid bed granulation process showed no signs of sticking when compressed on high speed commercial scale tablet compression machine.
