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MODULATEURS DE RECEPTEUR ANDROGENE SELECTIFS
专利权人:
PFIZER INC.
发明人:
ANDERSON, JAMES THOMAS,CHEKLER, EUGENE LVOVICH PIATNITSKI,ELLSWORTH, EDMUND L.,ERICKSON, BRUCE KIPP,GILBERT, ADAM MATTHEW,RICKETTS, ANTHONY P.,THOMPSON, DAVID P.,UNWALLA, RAYOMAND JAL,VERHOEST, PATRIC
申请号:
CA2891234
公开号:
CA2891234A1
申请日:
2013.11.25
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is CRe --, or, N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; Q is --CO--, --(CH2 )q --, --(CHRS )q --, or (CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.
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