Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.Linvention concerne des composés et des compositions pharmaceutiques qui modulent lactivité de kinase, notamment lactivité de kinase PI3, et des composés, des compositions pharmaceutiques, et des méthodes de traitement de maladies et daffections associées à lactivité de kinase, notamment lactivité de kinase PI3.