Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.La présente invention concerne des composés et des compositions pharmaceutiques qui modulent lactivité kinase, comprenant lactivité PI3 kinase, et des composés, des compositions pharmaceutiques, et des procédés de traitement de maladies et daffections associées à lactivité kinase, comprenant lactivité PI3 kinase.