Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.抗體或其抗原結合片段經生物工程以結合轉型生長因子-β(TGFβ)。相較於人類TGFβ2以及人類TGFβ3，TGFβ同型異構體選擇性抗體或其抗原結合片段可選擇性地結合人類TGFβ1，或相較於人類TGFβ1以及人類TGFβ2，該人類TGFβ同型異構體選擇性抗體或其抗原結合片段選擇性地結合人類TGFβ3。結合至TGFβ2之GC1008的重組Fab片段的共結晶結構以及結合至TGFβ1之GC1008的scFv變體的另一共結晶結構有助於設計該等抗體或其抗原結合片段。
