CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSERM (INSTITUT NATIONAL DE LA SANTÉ ET LA RECHERCHE MÉDICALE;UNIVERSITE DE NICE SOPHIA ANTIPOLIS-GRAND CHÂTEAU
发明人:
Jacob HECKSHER-SØRENSEN,Patrick COLLOMBAT
申请号：
US15538031
公开号：
US20170340591A1
申请日:
2015.12.23
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.
