This application provides preparations, methods, and substituted thieno[3,2‑d]pyrimidines, furo[3,2‑d]pyrimidines, and pyrrolo[] 3,2‑d]pyrimidine compounds, wherein the pneumonia virus subfamily virus infections include respiratory syncytial virus infections, and thieno[3,2‑d]pyrimidine and furo[3,2 for synthesis substitution ‑D] Methods and intermediates of pyrimidine and pyrrolo[3,2‑d] pyrimidine compounds.本申請提供了用於治療肺炎病毒亞科病毒感染的製劑、方法和式(I)的取代的噻吩并[3,2‑d]嘧啶、呋喃并[3,2‑d]嘧啶和吡咯并[3,2‑d]嘧啶化合物，其中所述肺炎病毒亞科病毒感染包括呼吸道合胞病毒感染，以及提供了用於合成取代的噻吩并[3,2‑d]嘧啶、呋喃并[3,2‑d]嘧啶和吡咯并[3,2‑d]嘧啶化合物的方法和中間體。
