There is provided herein treated with what include the preparation of Pneumovirinae virus infection of respiratory syncytial virus infection, method and formula (I) substituted tetrahydrofuran base-pyrrolo- [1,2-f][1,2,4] triazine -4- amine compounds and with what synthesizing tetrahydrofuran base-pyrrolo- [1,2-f][1,2,4] method and intermediate of triazine -4- amine compounds.本文提供了用於治療包括呼吸道合胞病毒感染的肺病毒亞科病毒感染的製劑、方法和式(I)的取代四氫呋喃基‑吡咯并[1,2‑f][1,2,4]三嗪‑4‑胺化合物以及用於合成四氫呋喃基‑吡咯并[1,2‑f][1,2,4]三嗪‑4‑胺化合物的方法和中間體。