The present disclosure provide catheter anchoring devices including anchoring devices that can be used to secure percutaneous catheters to a patient. In some embodiments, a catheter anchoring device comprises a locking tab having a front surface including a first mechanical engagement material and a back surface to be adhesively secured to a catheter by wrapping the back surface around a catheter surface. The catheter anchoring device further comprises a base portion comprising a base material layer including a bottom surface for adhesive application to the skin of a patient and a top surface including a second mechanical engagement material for engagement with the first mechanical engagement material of the locking tab and a flexible closure extending from the base material layer and including a third mechanical engagement material for engagement with the top surface of the base material layer and a through-hole sized to allow passage of a tab protrusion.
