A catheter tube anchoring device for securing a catheter to a patients skin, having two flexible side members and a rigid cross-member therebetween to which a retainer is mounted. The retainer holds a catheter adaptor at a 3-degree angle for patient comfort. Two rigid gripping tabs secure to each retainer side are gripped gripping while advancing a needle into the patients vein and while attaching the catheter adaptor to a I.V. tubing, for increased patient comfort, reduction of the risk in contamination and patient infection, and to more easily and quickly start an I.V. An alternative embodiment includes prism shaped tabs containing a pressure-release polymer adhesive-containing capsules which releases the polymer adhesive through mesh openings in the tabs onto an absorbent pad on a crosslmember bottom side and onto a patients skin to secure the device thereto either alone or in combination with a second adhesive on the patients skin.