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Oligonukleotydy pasujące do eksonu 73 w COL7A1 do leczenia pęcherzowego oddzielania się naskórka
专利权人:
Wings Therapeutics; Inc.
发明人:
HAISMA, ELISABETH MARLENE,POTMAN, MARKO,BEUMER, WOUTER,BRINKS, VERA
申请号:
PL16709465
公开号:
PL3268474T3
申请日:
2016.03.11
申请国别(地区):
PL
年份:
2020
代理人:
摘要:
Antisense oligonucleotides capable of preventing or reducing exon 73 inclusion into the human COL7A mRNA are characterized in various ways: (a) the oligonucleotide's sequence includes at most two CpG sequences; (b) the oligonucleotide has a length of no more than 24 nucleotides; (c) the oligonucleotide is capable of annealing to the (SRp40/SC35 binding/ESE) element in exon73. These oligonucleotides can usefully be oligoribonucleotides with modified internucleosidic linkages e.g. phosphorothioate linkages.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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