КОПЛЕНД Мхаири (GB),ДОРШ Марион (US),ЭРВИН Дейвид (GB),МАНЛИ Пол У. (CH),ПОЙКЕРТ Штефан (US)
申请号：
RU2012108930/15
公开号：
RU2012108930A
申请日:
2010.08.11
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A combination comprising a first agent that is a Smoothened inhibitor and a second agent that is a BCR-ABL inhibitor, where the first agent is a compound of formula I: wherein Y and Y are independently selected from N and CR, where R is selected from hydrogen, halogen, C -Salkyl, halogen-substituted C-C1-6alkyl, C-Salkoxy, halogen-substituted C-Salkoxy and -OXNRR, where R and R are independently selected from hydrogen and C-C1-6alkyl； halogen-substituted C-Salkoxygroup, C-Saryl, dimethyl other groups, C-C1-6alkylsulfanyl and C-Heterocycloalkyl, optionally substituted with one or two C-C1-6alkyls, R and R are independently selected from the group consisting of hydrogen, cyano, halogen, C-C1-6alkyl, halogen-substituted C-C1-6alkyl, C-alkoxy-substituted, halogen-substituted dimethylamino, R and R are independently selected from hydrogen, halogen, cyano, C-C1-6alkyl, halogen-substituted C-C1-6alkyl, C-Salkoxy and halogen-substituted C-Salkoxy； or R and R or R and R, together with the phenyl to which they are both attached, form C-heteroaryl, R and R are independently selected from hydrogen, C-C1-6alkyl, halogen-substituted C-C1-6alkyl, C-alkoxy and halogen-substituted C-alkoxy, provided that R and R are not are hydrogen, R is selected from hydrogen, halogen, C-C1-6alkyl, halogen-substituted C-C1-6alkyl, C-Salkoxy and halogen-substituted C-Salkoxy, R is selected from —S (O) R, —C (O) R, —OR, —NRR and —R where R is selected from aryl, heteroaryl, cycloalkyl and heterocycloalkyl, R and R are independently selected from C-C1-6alkyl and hydroxy-substituted C-C1-6alkyl and wherein said aryl, heteroaryl, cycloalkyl and heterocycloalkyl consisting of substituted Rneobyazatelno1. Комбинация, включающая первый агент, который является ингибитором Smoothened, и второй агент, который является ингибитором BCR-ABL, где первый агент представляет собой соединение формулы I:где Yи Yнезависимо выбраны из N и CR, где Rвыбран из водорода, галогена, C-Салкила, галогензамещенного C-Салкила
