CHRISTINE HIU CHEN,ZHUOLIANG TUNG - CHEN,MICHAEL DORE,JORGE GARCIA FORTANET,RAJESH KARKI,MITSUNORI KATO,MATTHEW J. LAMARCHE,LAWRENCE BLAS PEREZ,TROY DOUGLAS SMITH,SARAH WILLIAMS,JOHN WILLIAM GIRALDES
申请号：
ARP150100117
公开号：
AR100033A1
申请日:
2015.01.16
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
1. Claim 1: a formula compound (1),P from 0 and 1； Q from 0 and 1； Y1 from CH and N； Y2 from cr8310 and N； R1 es-xr1 7491；where R¹ᵃ is selected from aryl C₆₋₁₀,cycloalkyl C₃₋₈,C₃₋₈ cycloalkenyl and a 5-9 membered heteroaryl group containing 1 to 4 heteroatoms or groups independently selected from N, C (O),O and s, which are alien to arilo or r74919,is substituted with 1 to 5 R⁹ groups independently selected from halogen, amino, hydroxyl, N₃,1. Lease of c83218331 and 83242431；dimethyl amino, hydroxy substituted C₁₋₄ alkyl, halogen substituted C₁₋₄ alkyl, amino substituted C₁₋₄ alkyl, -C (O) OR¹⁰ and -NHC (O) R¹⁰；X is selected from the link, s (o)it is life.Cor1,CR RNumber 1；M selected from 0, 1 and 2； every r183044； 74919 and r183040； 7495；is independently selected from halogen and C₁₋₄-alkyl；YR1 was selected from hydrogen and hydrocarbon c8321c831832424；R²ᵃ and R²ᵇ are independently selected from hydrogen, C₁₋₄-alkyl,C₁₋₄ alkoxy,amino hidroxilo cicloalquilo Cand C₁₋₄-amino alkyl； R³ᵃ and R³ᵇ are independently selected from halogen, carbonyl, C₁₋₄ alkyl,C₁₋₄ alkoxy,amino hidroxilo cicloalquilo C1. C83218c83312424amino； r8308； 7491 and r8308； 74955；are independently selected from hydrogen, halogen, carbonyl, C₁₋₄-alkyl,C₁₋₄ alkoxy,amino hidroxilo cicloalquilo Cand C₁₋₄-amino alkyl； R⁵ᵃ and R⁵ᵇ are independently selected from hydrogen, carbonyl, C₁₋₄ alkyl,C₁₋₄ alkoxy,amino hidroxilo cicloalquilo Cand C₁₋₄-amino alkyl； where any two groups selected from R²ᵃ,74955,R3 7491,R3 degrees 7495；R⁴ᵃ,R⁴ᵇ,R⁵ᵃ,R⁵ᵇ,and R⁷ can form an unsaturated or partially saturated 5 to 6 membered ring； R⁶ is selected from hydrogen, halogen, cyano, C₁₋₄ alkyl,C₁₋₄ alkoxy,amino-carbonyl, C₁₋₄-alkyl substituted by halogen, C₁₋₄-alkoxy substituted by halogen, C₁₋₄-alkyl substituted by hydroxyl, C₁₋₄-alkyl substituted by amino, -S (O) ₁₋₂R⁶ᵃ,-C (S) R-C (o) No. 8310； No. 7491； No. r8310； No. 74955；-C (NH) No. 8310； No. 7491； No. r8310； No. 74955；y -NR C (O) Re. R8310；； 7491y r8310；； 749595 from c8332
