#$%^&*AU2009200906B220140403.pdf#####COMPOSITIONS USEFUL FOR THE TREATMENT OF DIABETES ABSTRACT The present invention provides a supramolecular insulin assembly and supramolecular exendin-4 assembly useful as protein therapeutics for the treatment of 5 metabolic disorders particularly diabetes. The supramolecular assemblies disclosed in the present invention consists of insoluble and aggregated oligomers the protein. The invention also provides pharmaceutical compositions comprising the supramolecular assembly.