Provided herein are isotopically enriched arylsulfonamides, for example, of Formula I, that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.本文提供一種同位素濃化之例如式I之芳磺醯胺及其醫藥組合物,該等芳磺醯胺可用於調節CCR3活性。本文亦提供一種使用其來治療、預防或改善CCR3介導之病症、疾病或病狀之一或多種症狀的方法。